How does hypothyroidism cause hyponatremia Usmle?

How does hypothyroidism cause hyponatremia Usmle?

The main mechanism for the development of hyponatremia in patients with chronic hypothyroidism is the decreased capacity of free water excretion due to elevated antidiuretic hormone levels, which are mainly attributed to the hypothyroidism-induced decrease in cardiac output.

Does hypothyroidism cause low sodium?

Patients with moderate to severe hypothyroidism and mainly patients with myxedema may exhibit reduced sodium levels (<135 mmol/L) (3, 4). Thus, hypothyroidism is one of the causes of hyponatremia, and TSH determination is mandatory during the evaluation of patients with reduced serum sodium levels (5, 6, 7).

Can elevated TSH cause hyponatremia?

Myxedema coma, characterized by chronic extreme thyroid-stimulating hormone (TSH) elevations, has repeatedly been linked to the development of hyponatremia [6,7,8], among many other complications.

Can hypothyroidism cause hypernatremia?

Low thyroid/glucocorticoid tone decreases free water clearance which protects against DI and may lead to hyponatremia while high thyroid/glucocorticoid tone may unmask DI and facilitate hypernatremia.

How does hypothyroidism cause adrenal insufficiency?

Treatment of hypothyroidism with thyroxine has been reported to precipitate addisonian crisis in patients who also have adrenal insufficiency. This may be due to an increase in metabolic rate induced by thyroid replacement therapy resulting in overt manifestations of adrenal insufficiency.

How does hypothyroidism cause hypoglycemia?

Hypothyroidism is linked with various hormonal biochemical and nervous system abnormalities, which may contribute to hypoglycemia. The condition is linked with low growth hormone and cortisol responses to insulin induced hypoglycemia, and this prevents adequate counter regulatory protection.

Can hypothyroidism cause electrolyte imbalance?

Hypothyroidism is one of the most prevalent endocrine diseases. It can lead to a variety of clinical situations, including congestive heart failure, electrolyte disturbances and coma. Hyponatremia is the most common electrolyte abnormality encountered in clinical practice (Kargili A et al, 2010).

Does levothyroxine affect sodium levels?

Serum sodium level improved only after optimal replacement therapy with Levothyroxine, which confirms the relationship of hyponatremia to thyroid hormone deficiency in this patient.

Can hyperthyroidism cause hypernatremia?

The clinical co-existence of diabetes insipidus and hyperthyroidism is very rare; however, the complication should be considered when hypernatremia and/or dehydration progress in patients with Graves’s disease as a common autoimmune-related etiology.

Does the thyroid affect the adrenal glands?

Your thyroid works in tandem with your adrenal glands. The adrenal glands, which are above your kidneys, can handle small amounts of stress well. When you encounter stress they release cortisol, which enhances various bodily functions.

How does Addison’s cause hyponatremia?

Hyponatremia and metabolic acidosis are major symptoms of adrenocortical dysfunction such as occurs in Addison’s disease. The hyponatremia is caused by insufficiency of both aldosterone and cortisol. Aldosterone insufficiency decreases sodium reabsorption in the collecting ducts of the kidney.

Does hypothyroidism cause low blood sugar?

Is there a link between hypothyroidism and hyponatremia?

However, recent data suggest that the hypothyroidism-induced hyponatremia is rather rare and probably occurs only in severe hypothyroidism and myxedema. Other possible causes and superimposed factors of hyponatremia (e.g. drugs, infections, adrenal insufficiency) should be considered in patients with mild/moderate hypothyroidism.

Which is the best treatment for mild hyponatremia?

Treatment of hypothyroidism and fluid restriction are usually adequate for the management of mild hyponatremia in patients with hypothyroidism. Patients with possible hyponatremic encephalopathy should be urgently treated according to current guidelines. Conclusions: Severe hypothyroidism may be the cause of hyponatremia.

Who is most at risk for hyponatraemia?

Background: Hyponatraemia is one of most common electrolyte abnormalities in acutely ill elderly patients. Severe hypothyroidism is often associated with hyponatraemia.

What was the blood test results for hyponatraemia?

Routine blood investigations showed she was hyponatraemic with Na 118 mmol/l, K 4.8 mmol/l, Urea 9.2 mmol/l and Creatinine 130 umol/l. Plasma Osmolality was 245 mosm/kg with urine osmolality 519 mosm/kg.

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